Alzheimer's Disease

A progressive neurologic disorder that causes the brain to shrink (atrophy) and brain cells to die. It is the most common cause of dementia; affecting memory, thinking and behavior.

Alzheimer's is a type of dementia that affects memory, thinking and behavior. Symptoms eventually grow severe enough to interfere with daily tasks. It is the most common cause of dementia; accounting for 60-80% of dementia cases.

Alzheimer's is not a normal part of aging.  

Symptoms

Symptoms of Alzheimer's disease progress slowly over the years. These symptoms can be confused with other illnesses and may initially be due to old age.  

The rate at which symptoms progress varies from person to person. Alzheimer's disease’s symptoms are divided according to the disease’s three main stages:

  1. Early symptoms:

In the early stages, the main symptom of Alzheimer's disease is memory lapses. This can be manifested in:

  • forget about recent conversations or events
  • misplace items
  • forget the names of places and objects
  • have trouble thinking of the right word
  • ask questions repetitively
  • show poor judgement or find it harder to make decisions
  • become less flexible and more hesitant to try new things

There are often signs of mood changes, such as increasing anxiety or agitation, or periods of confusion.

  1. Middle-stage symptoms:

As Alzheimer's disease progresses, memory problems worsen. People in this state may have increased difficulty remembering the names of people they know and recognizing family and friends.

Other symptoms may also appear like:

  • increasing confusion and disorientation – for example, getting lost, or wandering and not knowing what time of day it is
  • obsessive, repetitive, or impulsive behavior
  • delusions (believing things that are untrue) or feeling paranoid and suspicious about carers or family members
  • problems with speech or language (aphasia)
  • disturbed sleep
  • changes in mood, such as frequent mood swings, depression and feeling increasingly anxious, frustrated, or agitated
  • difficulty performing spatial tasks, such as judging distances
  • seeing or hearing things that other people do not (hallucinations)
  • Some people also have some symptoms of vascular dementia.

At this stage, patients with Alzheimer's disease usually need support in their daily lives (like in eating, washing, changing clothes, using the toilet, etc.)

  1. Later symptoms:

In the later stages of Alzheimer's disease, the symptoms become increasingly severe and can be distressing to the person, their caregivers, friends, and family. Hallucinations and delusions can come and go as the illness progresses but can worsen as the illness progresses. Alzheimer's patients at this stage sometimes can be violent, demanding, and distrustful of those around them.

Other symptoms that can appear as the disease progresses include:

  • difficulty eating and swallowing (dysphagia)
  • difficulty changing position or moving around without assistance
  • weight loss – sometimes severe
  • unintentional passing of urine (urinary incontinence) or stools (bowel incontinence)
  • gradual loss of speech
  • significant problems with short- and long-term memory

Prevalence

Most Alzheimer's patients are 65 and older. The risk of Alzheimer's disease and other types of dementia increases with age and is estimated to affect 1 in 14 people over the age of 65 and 1 in 6 people over the age of 80.

Prognosis

Alzheimer's disease shortens life expectancy. The period from diagnosis to death varies. If the patient is over 80 years old at the time of diagnosis, it is 3-4 years, and if he/she is younger, it is 10 years or more

When to seek help

Treatment

Sadly, Alzheimer's has no cure, but one treatment — aducanumab (Aduhelm™) — is the first treatment that has been shown to be very likely to alleviate cognitive decline in people with early-stage Alzheimer's disease.

Other treatments can temporarily slow the exacerbation of dementia symptoms and improve the quality of life for people with Alzheimer's disease and their caregivers. These include:

  • Medicines like Acetylcholinesterase (AChE) inhibitors and Memantine (for severe Alzheimer’s cases).  
  • Medicines to treat challenging behavior: If coping strategies do not work, a consultant psychiatrist can prescribe risperidone or haloperidol, antipsychotic medicines, for those showing persistent aggression or extreme distress.  

N.B.: Each of these medicines must be prescribed by a consultant psychiatrist and the patient must be closely monitored during the treatment process to detect any serious side effects as soon as possible. Antidepressants may also be prescribed depending on the case.

  • Cognitive Stimulation Therapy: Involves participating in group activities and exercises designed to enhance memory and problem-solving skills.
  • Cognitive Rehabilitation: Involves working with a trained professional, such as an occupational therapist, and a relative or friend to achieve a personal goal, like learning to use a mobile phone or other everyday tasks. The goal here is to get you to use the parts of your brain that are working to help the parts that are not.
  • Reminiscence and life story work: Involves strategies like talking about things and events from your past. It usually involves using props such as photos, favorite belongings, or music. Evidence shows they can enhance mood and wellbeing.